| Identification | Back Directory | [Name]
CCI 006) | [CAS]
292053-42-0 | [Synonyms]
CCI 006)
CCI-006
(CCI006
2-Propenoic acid, 3-[5-[4-(aminosulfonyl)phenyl]-2-furanyl]-2-cyano-, methyl ester | [Molecular Formula]
C15H12N2O5S | [MDL Number]
MFCD01847328 | [MOL File]
292053-42-0.mol | [Molecular Weight]
332.33 |
| Hazard Information | Back Directory | [Uses]
CCI-006 is a selective inhibitor and chemosensitizer of MLL-rearranged leukemia cells, by inhibits mitochondrial respiration resulting in insurmountable mitochondrial depolarization and a pro-apoptotic unfolded protein response (UPR) in a subset of MLL-r leukemia cells[1]. | [storage]
Store at -20°C | [References]
[1] Somers K, et al. A novel small molecule that kills a subset of MLL-rearranged leukemia cells by inducing mitochondrial dysfunction. Oncogene. 2019 Jan 22. DOI:10.1038/s41388-018-0666-5 |
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| Company Name: |
Merck KGaA
|
| Tel: |
21-20338288 |
| Website: |
www.sigmaaldrich.cn |
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