| Chemical Properties | Back Directory | [Boiling point ]
838.0±65.0 °C(predicted) | [density ]
1.41±0.1 g/cm3(Temp: 20 °C; Press: 760 Torr)(predicted) | [form ]
Solid | [pka]
10.01±0.46(predicted) | [color ]
White to off-white |
| Hazard Information | Back Directory | [Uses]
SARS-CoV-2-IN-41 (compound 2) is a potent SARS-CoV-2 3CLpro inhibitor with an IC50 value of 0.022 μM. SARS-CoV-2-IN-41 shows antiviral effect[1]. | [in vivo]
SARS-CoV-2-IN-41 (50, 200 mg/kg; I.p.) antiviral effect in SARS-CoV-2 infected mice[1]. | Animal Model: | 7-8 weeks, hACE2-K18 transgenic mice (infected with the delta strain of SARS-CoV-2 by intranasal drops)[1] | | Dosage: | 50, 200 mg/kg (combined with 50 mg/kg cytochrome P450 inhibitor ritonavir) | | Administration: | I.p.; dose on day 0 1 time, 2 times on the 1st day, 1 time on the 2nd day | | Result: | Significantly reduced the viral load in the lungs, after 4 days of infection, a sustained inhibitory effect of compound 2 on viral copy number was observed. |
| [References]
[1] XiangRui et al. Cyano compound, and preparation method therefor and use thereof. WO2023051657A1. |
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