| Identification | Back Directory | [Name]
3β-Hydroxy-5α-lanosta-7,9(11),24-trien-21-oic acid | [CAS]
29220-16-4 | [Synonyms]
Poricoic acid
11,24-trien-21-oic acid
3beta-Hydroxylanosta-7,9
3-dehydrotrametenolic acid
3β-Hydroxylanosta-7,9(11),24-trien-21-oic acid
3beta-Hydroxylanosta-7,9(11),24-trien-21-oic acid
3β-Hydroxy-5α-lanosta-7,9(11),24-trien-21-oic acid
Lanosta-7,9(11),24-trien-21-oic acid, 3-hydroxy-, (3β)-
Dehydrotrametenolic acid
3β-hydroxylanosta-7,
9(11),24-trien-21-oic
acid
Dehydrotrametenolic acid 3β-hydroxylanosta-7, 9(11),24-trien-21-oic acid | [Molecular Formula]
C30H46O3 | [MDL Number]
MFCD29059660 | [MOL File]
29220-16-4.mol | [Molecular Weight]
454.68 |
| Chemical Properties | Back Directory | [Melting point ]
257-259℃ | [Boiling point ]
585.4±50.0 °C(Predicted) | [density ]
1.08±0.1 g/cm3(Predicted) | [storage temp. ]
Sealed in dry,Room Temperature | [solubility ]
Soluble in Chloroform,Dichloromethane,Ethyl Acetate,DMSO,Acetone,etc. | [form ]
Powder | [pka]
4.63±0.10(Predicted) | [color ]
White to off-white | [InChIKey]
QFPLAAZRZNKRRY-XUJPXTKYNA-N | [SMILES]
[C@@H]1(O)C(C2[C@](C)(CC1)C1C([C@]3([C@@](CC=1)(C)[C@@H]([C@H](C(O)=O)CC/C=C(\C)/C)CC3)C)=CC2)(C)C |&1:0,4,10,11,15,16,r| |
| Hazard Information | Back Directory | [Description]
Dehydrotrametenolic acid (DTA) is a lanostane-type triterpene acid isolated from Poria cocos Wolf (Polyporaceae)，and has an anti-inflammatory and antidiabetic effects. The regulatory effects of DTA on skin hydration and keratinocyte differentiation are mediated by the MAPK/AP-1 and IκBα/NF-κB pathways. In addition, Dehydrotrametenolic acid could be a promising ingredient in cosmetics for moisturizing and increased skin barrier function.[1] | [Chemical Properties]
White crystalline powder, soluble in organic solvents such as methanol, ethanol, and DMSO, derived from Poria cocos. | [Uses]
3-?Dehydrotrametenolic acid, isolated from the sclerotium of Poria cocos, is a lactate dehydrogenase (LDH) inhibitor. 3-?Dehydrotrametenolic acid promotes adipocyte differentiation in vitro and acts as an insulin sensitizer in vivo. 3-?Dehydrotrametenolic acid induces apoptosis and has anticancer activity[1][2]. | [Biological Activity]
3-Dehydrotrametenolic acid, isolated from the sclerotium of Poria cocos, is a lactate dehydrogenase (LDH) inhibitor. 3-Dehydrotrametenolic acid promotes adipocyte differentiation in vitro and acts as an insulin sensitizer in vivo. 3-Dehydrotrametenolic acid induces apoptosis and has anticancer activity. | [References]
[1] EUNJU CHOI. In Vitro Effects of Dehydrotrametenolic Acid on Skin Barrier Function.[J]. ACS Applied Energy Materials, 2019. DOI:10.3390/molecules24244583.
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