| Identification | Back Directory | [Name]
Ethanone, 1-[4-[4-[[(1R)-1-[3-(difluoromethyl)-2-fluorophenyl]ethyl]amino]-1,7-naphthyridin-6-yl]-1-piperazinyl]- | [CAS]
2922069-42-7 | [Synonyms]
Ethanone, 1-[4-[4-[[(1R)-1-[3-(difluoromethyl)-2-fluorophenyl]ethyl]amino]-1,7-naphthyridin-6-yl]-1-piperazinyl]- | [Molecular Formula]
C23H24F3N5O | [MOL File]
2922069-42-7.mol | [Molecular Weight]
443.47 |
| Chemical Properties | Back Directory | [Boiling point ]
616.8±55.0 °C(predicted) | [density ]
1.327±0.06 g/cm3(Temp: 20 °C; Press: 760 Torr)(predicted) | [pka]
7.73±0.30(predicted) |
| Hazard Information | Back Directory | [Uses]
HH0043 (Compound 10f) is an orally active and potent SOS1 inhibitor, with IC50 value of 5.8 nM. HH0043 can be used for the research of cancer[1]. | [References]
[1] Li D, et al. Lead Identification of Novel Naphthyridine Derivatives as Potent SOS1 Inhibitors. ACS Med Chem Lett. 2024 Jun 3;15(6):958-964. DOI:10.1021/acsmedchemlett.4c00156 |
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