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Topo II/HDAC-IN-2 (8d) exhibits excellent dual inhibitory activities against Topo II and HDAC. Topo II/HDAC-IN-2 (8d) induces apoptosis[1]. | [References]
[1] Mengmiao Zhao,
et al. Design, synthesis and biological evaluation of dual Topo II/HDAC
inhibitors bearing pyrimido[5,4-b]indole and pyrazolo[3,4-d]pyrimidine motifs. Eur
J Med Chem.?2023 Apr 5;252:115303. DOI:10.1016/j.ejmech.2023.115303 |
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