| Identification | Back Directory | [Name]
2,1-Benzisoxazole-5-carboxylic acid, 3-[1,1′-biphenyl]-4-yl- | [CAS]
2922283-43-8 | [Synonyms]
2,1-Benzisoxazole-5-carboxylic acid, 3-[1,1′-biphenyl]-4-yl- | [Molecular Formula]
C20H13NO3 | [MOL File]
2922283-43-8.mol | [Molecular Weight]
315.32 |
| Chemical Properties | Back Directory | [Boiling point ]
599.2±35.0 °C(Predicted) | [density ]
1.299±0.06 g/cm3(Temp: 20 °C; Press: 760 Torr)(Predicted) | [form ]
Solid | [pka]
3.62±0.30(Predicted) | [color ]
Light yellow to yellow |
| Hazard Information | Back Directory | [Uses]
UNC7467 is a potent IP6K inhibitor with values of 4.9, 8.9 and 1320 nM for IP6K2, IP6K1 and IP6K6, respectively. UNC7467 reduces levels of inositol pyrophosphates. UNC7467 can be used for obesity research[1]. | [in vivo]
UNC7467 (5 mg/kg; i.p.; daily, for 4 weeks; diet-induced obesity mice) ameliorated diet induced obesity, insulin resistance, and hepatic steatosis[1].
UNC7467 (1-5 mg/kg; i.v. and i.p.; diet-induced obesity mice) exhibits low clearance (13.7 (mL/min)/kg) and large AUClast (6054 h?ng/mL for intra venous (i.v.) and 2527 h?ng/mL for intraperitoneal (i.p.)) in mice at 5 mg/kg dose[1]. | Animal Model: | Diet-induced obesity (DIO) mice[1] | | Dosage: | 5 mg/kg | | Administration: | Intraperitoneal injection; daily, for 4 weeks | | Result: | Improved glycemic profiles, ameliorated hepatic steatosis, and reduced weight gain without altering food intake. |
| Animal Model: | Diet-induced obesity (DIO) mice[1] | | Dosage: | 5 mg/kg (Pharmacokinetic Analysis) | | Administration: | Intravenous injection and intraperitoneal injection | | Result: | 1.19| route | iv | ip | | Dose (mg/kg) | 5 | 5 | | AUClast (h*ng/mL) | 6054 | 2527 | | CL (mL/min/kg) | 13.7 | |
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| [References]
[1] Zhou Y, et, al. Development of Novel IP6K Inhibitors for the Treatment of Obesity and Obesity-Induced Metabolic Dysfunctions. J Med Chem. 2022 May 12;65(9):6869-6887. DOI:10.1021/acs.jmedchem.2c00220 |
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| Company Name: |
Wuhan Topule
|
| Tel: |
+86-02787215551 +86-19945035818 |
| Website: |
http://www.topule.com/ |
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