| Chemical Properties | Back Directory | [Boiling point ]
640.575±65.00 °C(Press: 760.00 Torr)(predicted) | [density ]
1.498±0.10 g/cm3(Temp: 25 °C; Press: 760 Torr)(predicted) | [form ]
Solid | [pka]
0.210±0.22(predicted) | [color ]
White to off-white |
| Hazard Information | Back Directory | [Uses]
GPR183 antagonist-2 (compound 32) is a selective GPR183 antagonist with good water solubility and excellent pharmacokinetic properties. GPR183 antagonist-2 significantly reduces paw and joint swelling and gene expression of pro-inflammatory cytokines (MCP-1, MMPs, and VEGF) in a collagen-induced arthritis (CIA) mouse model in a dose-dependent manner. GPR183 antagonist-2 can be used in the study of autoimmune diseases[1]. | [References]
[1] Xi J, et al. Discovery of a First-in-Class GPR183 Antagonist for the Potential Treatment of Rheumatoid Arthritis. J Med Chem. 2023 Dec 14;66(23):15926-15943. DOI:10.1021/acs.jmedchem.3c01364 |
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