| Hazard Information | Back Directory | [Uses]
GPR183-IN-2 (compound 23) is a potent GPR183 inhibitor. GPR183-IN-2 inhibits Ca2+ mobilization with an IC50 value of 39.45 nM. GPR183-IN-2 has the potential for the research of cancer, autoimmune diseases, pain, and osteoporosis[1]. | [in vivo]
Pharmacokinetic Parameters[1].
| Parameters | CL (mL/min/kg) | T1/2 (h) | Cmax (ng/mL) | AUC0-t (ng?h/mL) | Vss (L/kg) | F (%) | | IV 1 mg/kg | 10.17 | 1.91 | 965 | 1575 | 1.50 | - | | PO 10 mg/kg | - | 4.58 | 5108 | 28042 | - | 224.50 |
| [References]
[1] Jian Bei Xi, et al. Compounds and their use as GPR183 inhibitors. CN118201911A. |
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