| Identification | Back Directory | [Name]
4(1H)-Quinazolinone, 2,3-dihydro-2-(1H-indol-5-yl)- | [CAS]
2924156-96-5 | [Synonyms]
4(1H)-Quinazolinone, 2,3-dihydro-2-(1H-indol-5-yl)- | [Molecular Formula]
C16H13N3O | [MOL File]
2924156-96-5.mol | [Molecular Weight]
263.29 |
| Chemical Properties | Back Directory | [Boiling point ]
638.7±55.0 °C(predicted) | [density ]
1.306±0.06 g/cm3(Temp: 20 °C; Press: 760 Torr)(predicted) | [pka]
12.58±0.40(predicted) |
| Hazard Information | Back Directory | [Uses]
Tubulin polymerization-IN-68 (compound 32) is a tubulin inhibitor that can inhibit tubulin polymerization and destroy the cellular microtubule network. Tubulin polymerization-IN-68 can upregulate the expression of PARP-1 and caspase-3 and induce cell apoptosis, and has anticancer activity. Tubulin polymerization-IN-68 can effectively inhibit HepG2 (IC50=93 nM) and significantly inhibit the growth of HepG2 xenograft tumors in nude mice by oral administration[1]. | [References]
[1] Discovery of novel 2-substituted 2, 3-dihydroquinazolin-4(1H)-one derivatives as tubulin polymerization inhibitors for anticancer therapy: The in vitro and in vivo biological evaluation |
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