| Chemical Properties | Back Directory | [density ]
1.343±0.06 g/cm3(Temp: 25 °C; Press: 760 Torr)(predicted) | [form ]
Solid | [pka]
8.480±0.10(predicted) | [color ]
Off-white to light yellow |
| Hazard Information | Back Directory | [Uses]
PB131 is a selective and brain-permeable HDAC6 inhibitor with high binding affinity (IC50: 1.8 nM). PB131 has potent anti-inflammatory activity. PB131 can be used for research of inflammation, especially neuroinflammation[1]. | [References]
[1] Liu G, et al. Design, synthesis, and anti-inflammatory activity characterization of novel brain-permeable HDAC6 inhibitors. Eur J Med Chem. 2023 Jun 5;254:115327. DOI:10.1016/j.ejmech.2023.115327 |
|
|