| Chemical Properties | Back Directory | [Boiling point ]
608.612±30.00 °C(Press: 760.00 Torr)(predicted) | [density ]
1.130±0.06 g/cm3(Temp: 25 °C; Press: 760 Torr)(predicted) | [form ]
Solid | [pka]
14.564±0.46(predicted) | [color ]
White to off-white |
| Hazard Information | Back Directory | [Uses]
AChE/BChE-IN-10 (Compound 7b) is a potent dual AChE and BChE inhibitor with IC50 values of 0.176, and 0.47 μM, respectively. AChE/BChE-IN-10 shows good blood brain barrier permeability. AChE/BChE-IN-10 can inhibit Aβ-aggregation and be used in Alzheimer’s disease (AD) research[1]. | [IC 50]
AChE: 0.176 μM (IC50); BChE: 0.47 μM (IC50) | [References]
[1] Mohd Abdullaha, et al. Discovery of methoxy-naphthyl linked N-(1-benzylpiperidine) benzamide as a blood-brain permeable dual inhibitor of acetylcholinesterase and butyrylcholinesterase. Eur J Med Chem. 2020 Dec 1;207:112761. DOI:10.1016/j.ejmech.2020.112761 |
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