| Identification | Back Directory | [Name]
Thalidomide-N-methylpiperazine | [CAS]
2924858-30-8 | [Synonyms]
Thalidomide-N-methylpiperazine
1H-Isoindole-1,3(2H)-dione, 2-(2,6-dioxo-3-piperidinyl)-5-(4-methyl-1-piperazinyl)- | [Molecular Formula]
C18H20N4O4 | [MOL File]
2924858-30-8.mol | [Molecular Weight]
356.38 |
| Chemical Properties | Back Directory | [Boiling point ]
618.9±55.0 °C(predicted) | [density ]
1.397±0.06 g/cm3(Temp: 20 °C; Press: 760 Torr)(predicted) | [pka]
10.83±0.40(predicted) |
| Hazard Information | Back Directory | [Uses]
Thalidomide-N-methylpiperazine is an E3 Ligase Ligand-Linker Conjugate. Thalidomide-N-methylpiperazine can be used to synthesize PROTAC MLKL Degrader-2 (HY-169072) [1] to exhibit antinecroptotic activity on human cell lines and effectively degrade MLKL in the HT-29 xenograft mouse model[1]. | [References]
[1] Li S, et al. Discovery of Covalent MLKL PROTAC Degraders via Optimization of a Theophylline Derivative Ligand for Treating Necroptosis. J Med Chem. 2024 Sep 12;67(17):15353-15372. DOI:10.1021/acs.jmedchem.4c00949 |
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