| Chemical Properties | Back Directory | [Boiling point ]
635.1±65.0 °C(predicted) | [density ]
1.45±0.1 g/cm3(Temp: 20 °C; Press: 760 Torr)(predicted) | [form ]
Solid | [pka]
10.74±0.10(predicted) | [color ]
White to off-white |
| Hazard Information | Back Directory | [Uses]
hCAIX-IN-18 (compound 30) is an inhibitor of carbonic anhydrase (CA), with Kis of 3.5 nM, 9.4 nM, 43.0 nM and 8.2 nM for hCAI, hCAII, hCAIX, hCAXII, respectively. hCAIX-IN-18 can be used for cancer research[1]. | [IC 50]
hCA I: 3.5 nM (IC50); hCA II: 9.4 nM (IC50); hCA IX: 43 nM (IC50); hCA XII: 8.2 nM (IC50) | [References]
[1] 1. Peerzada MN, et al. Discovery of Novel Hydroxyimine-Tethered Benzenesulfonamides as Potential Human Carbonic Anhydrase IX/XII Inhibitors. ACS Med Chem Lett. 2023 May 8;14(6):810-819. DOI:10.1021/acsmedchemlett.3c00094 |
|
|