| Identification | Back Directory | [Name]
UNC8153 TFA | [CAS]
2929304-61-8 | [Synonyms]
UNC8153 TFA
2H-1,4-Benzoxazine-7-carboxamide, N-[[4-[[[4-[[(6-aminohexyl)amino]carbonyl]phenyl]amino]carbonyl]phenyl]methyl]-N-cyclopropyl-3,4-dihydro-3-oxo-, 2,2,2-trifluoroacetate (1:1) | [Molecular Formula]
C33H37N5O5.C2HF3O2 | [MOL File]
2929304-61-8.mol | [Molecular Weight]
697.7 |
| Hazard Information | Back Directory | [Uses]
UNC8153 TFA is a potent and selective nuclear receptor-binding SET domain-containing 2 (NSD2)-targeted degrader with a Kd of 24 nM. UNC8153 TFA reduces the cellular levels of both NSD2 protein and the H3K36me2 chromatin mark. UNC8153 TFA contains a simple warhead that confers proteasome-dependent degradation of NSD2[1]. | [References]
[1] Ronan P Hanley, et al. Discovery of a Potent and Selective Targeted NSD2 Degrader for the Reduction of H3K36me2. J Am Chem Soc. 2023 Apr 12;145(14):8176-8188. DOI:10.1021/jacs.3c01421 |
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