| Identification | Back Directory | [Name]
Resomelagon methanesulfonate | [CAS]
2933183-20-9 | [Synonyms]
Resomelagon methanesulfonate
Hydrazinecarboximidamide, 2-[(2E)-3-[1-(2-nitrophenyl)-1H-pyrrol-2-yl]-2-propen-1-ylidene]-, (2E)-, compd. with methanesulfonate (1:1) | [Molecular Formula]
C14H14N6O2.CH4O3S | [MOL File]
2933183-20-9.mol | [Molecular Weight]
394.41 |
| Hazard Information | Back Directory | [Uses]
Resomelagon methanesulfonate (AP1189 methanesulfonate) is the methanesulfonate salt form of Resomelagon (HY-147301). Resomelagon methanesulfonate is an orally active melanocortin receptor (MR) agonist. Resomelagon methanesulfonate induces ERK1/2 phosphorylation and Ca2+ mobilization. Resomelagon methanesulfonate exhibits anti-inflammatory activity in mouse peritonitis and peritonitis model. Resomelagon methanesulfonate can be used for obesity and chronic inflammation research[1][2]. | [References]
[1] Montero-Melendez T, et, al. Biased agonism as a novel strategy to harness the proresolving properties of melanocortin receptors without eliciting melanogenic effects. J Immunol. 2015 Apr 1;194(7):3381-8. DOI:10.4049/jimmunol.1402645
[2] WHO Drug Information. International Nonproprietary Names for Pharmaceutical. |
|
| Company Name: |
Biorbyt Ltd.
|
| Tel: |
+44 (0)1223 859 353 |
| Website: |
http://www.biorbyt.com |
|