| Chemical Properties | Back Directory | [density ]
1.41±0.1 g/cm3(Temp: 20 °C; Press: 760 Torr)(predicted) | [form ]
Solid | [pka]
16.99±0.30(predicted) | [color ]
Light yellow to yellow |
| Hazard Information | Back Directory | [Uses]
Tubulin/JAK2-IN-1 (compound 7g) is a dual inhibitor of Janus kinase 2 (JAK2) and microtubule. Tubulin/JAK2-IN-1 has potent antiproliferative activity against the cancer cells[1]. | [References]
[1] Li Chen, et al. Design, Synthesis, and Antitumor Efficacy of Substituted 2-Amino[1,2,4]triazolopyrimidines and Related Heterocycles as Dual Inhibitors for Microtubule Polymerization and Janus Kinase 2. J Med Chem. 2023. DOI:10.1021/acs.jmedchem.3c01690 |
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