| Chemical Properties | Back Directory | [Boiling point ]
518.6±50.0 °C(predicted) | [density ]
1.069±0.06 g/cm3(Temp: 20 °C; Press: 760 Torr)(predicted) | [pka]
11.07±0.70(predicted) |
| Hazard Information | Back Directory | [Uses]
CSF1R-IN-23 (Compound 7dri) is a selective inhibitor for colony-stimulating factor-1 receptor (CSF1R), with IC50 of 36.1 nM. CSF1R-IN-23 serves as antineuroinflammatory agent in mouse model. CSF1R-IN-23 is blood brain barrier (BBB) permeable[1]. | [in vivo]
CSF1R-IN-23 (0.5 mg/kg, i.p. every two days for 4 doses) ameliorates the Lipopolysaccharide (HY-D1056)-induced neuroinflammation in C57BL/6J mice model[1]. | Animal Model: | LPS-induced neuroinflammation in C57BL/6J mice model[1] | | Dosage: | 0.5 mg/kg | | Administration: | i.p., every two days for 4 doses | | Result: | Eliminated the 76% microglias in hippocampus, cortex, and thalamus. |
| [References]
[1] Baek J, et al., Targeting the CSF-1/CSF-1R Axis: Exploring the Potential of CSF1R Inhibitors in Neurodegenerative Diseases. J Med Chem. 2024 Apr 11;67(7):5699-5720. DOI:10.1021/acs.jmedchem.3c02366 |
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