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2936625-34-0

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2936625-34-0 Structure

2936625-34-0 Structure
IdentificationBack Directory
[Name]

6-fluoro-3-(2,4,5-trifluoro-3-methoxyphenyl)benzo[b]thiophene-2-carboxylic acid
[CAS]

2936625-34-0
[Synonyms]

PF-07328948
6-fluoro-3-(2,4,5-trifluoro-3-methoxyphenyl)benzo[b]thiophene-2-carboxylic acid
Chemical PropertiesBack Directory
[form ]

Solid
[color ]

White to light yellow
Hazard InformationBack Directory
[Uses]

PF-07328948 is an orally effective BDK (branch chain ketoacid dehydrogenase kinase) inhibitor, with IC50 of 110 nM. PF-07328948 acts as a BCKDH (branch chain ketoacid dehydrogenase) enzyme complex degrader to enhance BCAA (branch chain amino acid) catabolism. PF-07328948 improves metabolic and heart failure end points in rats[1].
[in vivo]

PF-07328948 (chow formulated with PF-07328948, p.o., 11 weeks) improves metabolic and heart failure end points in ZSF1 rats.[1].

[References]

[1] Filipski KJ, et al. Discovery of First Branched-Chain Ketoacid Dehydrogenase Kinase (BDK) Inhibitor Clinical Candidate PF-07328948. J Med Chem. 2024 Nov 19. DOI:10.1021/acs.jmedchem.4c02230
Spectrum DetailBack Directory
[Spectrum Detail]

6-fluoro-3-(2,4,5-trifluoro-3-methoxyphenyl)benzo[b]thiophene-2-carboxylic acid(2936625-34-0)1HNMR
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