| Identification | Back Directory | [Name]
RO 90-7501 | [CAS]
293762-45-5 | [Synonyms]
RO90-7501; RO 907501
2'-(4-aMinophenyl)-1H,3'H-2,5'-bibenzo[d]iMidazol-6-aMine | [Molecular Formula]
C20H16N6 | [MDL Number]
MFCD07784512 | [MOL File]
293762-45-5.mol | [Molecular Weight]
340.388 |
| Hazard Information | Back Directory | [Uses]
Ro 90-7501 exhibits antibacterial activity. In addition, it also promote both toll-like receptor 3 (TLR3) and RIG-I-like receptor (RLR) ligand-induced IFN-β gene expression and antiviral response. | [Definition]
ChEBI: 2-[2-(4-aminophenyl)-3H-benzimidazol-5-yl]-3H-benzimidazol-5-amine is a member of benzimidazoles. | [Biological Activity]
Inhibitor of amyloid β 42 (A β 42) fibril assembly; reduces A β 42-induced toxicity (EC 50 = 2 μ M). | [in vivo]
Ro 90-7501 (5 μg/g; intraperitoneal injection; daily; for 21 days; female BALB/c nude mice) treatment significantly delays tumor growth and significantly decreases tumor volume[1]. | Animal Model: | Female BALB/c nude mice (8-week-old) with HeLa cells under irradiation[1] | | Dosage: | 5 μg/g | | Administration: | Intraperitoneal injection; daily; for 21 days | | Result: | Tumor growth was significantly delayed in the combination group. Tumor volume was also significantly decreased in the irradiation group.
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| [IC 50]
Amyloid β42; ATM; Protein phosphatase 5; Apoptosis | [storage]
Store at +4°C |
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| Company Name: |
Energy Chemical
|
| Tel: |
021-58432009 400-005-6266 |
| Website: |
http://www.energy-chemical.com |
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