| Identification | Back Directory | [Name]
5-bromo-4-chloro-1H-indazol-3-amine | [CAS]
2939840-50-1 | [Synonyms]
5-bromo-4-chloro-1H-indazol-3-amine
1H-Indazol-3-amine, 5-bromo-4-chloro- | [Molecular Formula]
C7H5BrClN3 | [MOL File]
2939840-50-1.mol | [Molecular Weight]
246.49 |
| Chemical Properties | Back Directory | [Boiling point ]
467.525±40.00 °C(Press: 760.00 Torr)(predicted) | [density ]
1.964±0.06 g/cm3(Temp: 25 °C; Press: 760 Torr)(predicted) | [pka]
11.707±0.10(predicted) |
| Hazard Information | Back Directory | [Synthesis]
To a rigorously cleaned, nitrogen-purged 1L Parr reactor equipped with a stainless-steel stirrer shaft and turbine-type impeller was charged 3-bromo-2,6-dichlorobenzonitrile (80.0 g, 1 eq, 296 mmol), hydrazine hydrate (76 mL, 4 eq, 1.2 mol), sodium acetate (29.1, 1.2 eq, 355 mmol) and 2-MeTHF (5 V, 400 mL) at room temperature. The reaction mixture was warmed to 105 °C (45 psig) and held at this temperature for 18h. Upon completion, the crude mixture (5-bromo-4-chloro-1H-indazol-3-amine and 7-Bromo-4-chloro-1H-indazol-3-ylamine) was slowly cooled to -25°C.
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