| Identification | Back Directory | [Name]
h-NTPDase-IN-5 | [CAS]
2939932-93-9 | [Synonyms]
h-NTPDase-IN-5
Thieno[3,2-d]pyrimidine, 4-(4-morpholinyl)-7-[4-(phenylmethoxy)phenyl]- | [Molecular Formula]
C23H21N3O2S | [MOL File]
2939932-93-9.mol | [Molecular Weight]
403.5 |
| Chemical Properties | Back Directory | [Boiling point ]
623.784±55.00 °C(Press: 760.00 Torr)(predicted) | [density ]
1.290±0.06 g/cm3(Temp: 25 °C; Press: 760 Torr)(predicted) | [pka]
5.184±0.30(predicted) |
| Hazard Information | Back Directory | [Uses]
h-NTPDase-IN-5 (compound 3b) is a pan-inhibitor of NTPDase with IC50s of 1.10 μM (h-NTPDase1), 44.73 μM (h-NTPDase2), 26.14 μM (h-NTPDase3), 0.32 μM (h- NTPDase8). | [References]
[1] Zaman G, Ullah S, Uzair M, et al. Synthesis of Thieno [3, 2‐d] pyrimidine Derivatives through Sequential SNAr and Suzuki Reactions as Selective h‐NTPDases Inhibitors[J]. ChemMedChem, 2023: e202300165. |
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