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29444-03-9

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29444-03-9 Structure

29444-03-9 Structure
IdentificationBack Directory
[Name]

Jatrophone
[CAS]

29444-03-9
[Synonyms]

NSC135037
NSC-135037
Jatrophone
NSC 135037
Jatropha principle
(2R,3aR,9E,12Z)-2,3,7,8-Tetrahydro-2,5,8,8,12-pentamethyl-3a,6-epoxy-3aH-cyclopentacyclododecene-4,11-dione
3a,6-Epoxy-3aH-cyclopentacyclododecene-4,11-dione, 2,3,7,8-tetrahydro-2,5,8,8,12-pentamethyl-, (2R,3aR,9E,12Z)-
[Molecular Formula]

C20H24O3
[MDL Number]

MFCD09837890
[MOL File]

29444-03-9.mol
[Molecular Weight]

312.4
Chemical PropertiesBack Directory
[Definition]

A diterpenoid growth inhibitor isolated from an alcohol extract of the plant Jatropha gossypiifolia. Its unique structure includes a 12membered ring. It is readily attacked by nucleophiles. Useful in study of tumor growth inhibition and other biochemica
Hazard InformationBack Directory
[Uses]

Jatrophone is a diterpenoid with anticancer activity isolated from Jatropha isabelli. Jatrophone interferes with the Wnt/β-catenin pathway to inhibit the proliferation and epithelial-mesenchymal transition (EMT) of triple-negative breast cancer cells.
[References]

[1] The natural compound Jatrophone interferes with Wnt/β-catenin signaling and inhibits proliferation and EMT in human triple-negative breast cancer
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