| Identification | Back Directory | [Name]
Spiro[3H-indole-3,2'(3'H)-[1,3,4]thiadiazol]-2(1H)-one, 5-ethyl-5'-phenyl- | [CAS]
294648-66-1 | [Synonyms]
ADAMTS-5-IN-2
Spiro[3H-indole-3,2'(3'H)-[1,3,4]thiadiazol]-2(1H)-one, 5-ethyl-5'-phenyl- | [Molecular Formula]
C17H15N3OS | [MOL File]
294648-66-1.mol | [Molecular Weight]
309.39 |
| Hazard Information | Back Directory | [Uses]
ADAMTS-5-IN-2 (compound 25) is a potent ADAMTS-5 inhibitor with an IC50 value of 0.71 μM. ADAMTS-5-IN-2 has the potential for the research of modifying osteoarthritis[1][2]. | [References]
[1] Bompiani KM, et al. High-Throughput Screening Uncovers Novel Botulinum Neurotoxin Inhibitor Chemotypes. ACS Comb Sci. 2016 Aug 8;18(8):461-74. DOI:10.1021/acscombsci.6b00033
[2] Matthew G. Bursavich; et al. 5′-Phenyl-3′H-spiro[indoline-3,2′-[1,3,4]thiadiazol]-2-one inhibitors of ADAMTS-5 (Aggrecanase-2). Bioorganic & Medicinal Chemistry Letters. 2007, 17(20), 5630-5633. |
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