| Identification | Back Directory | [Name]
17-trifluoromethylphenyl-13,14-dihydro trinor Prostaglandin F2α | [CAS]
294856-01-2 | [Synonyms]
GGAGMUSEFHEEBF-XPRPYWGDSA-N
17-trifluoromethylphenyl-13,14-dihydro trinor Prostaglandin F2α
5-Heptenoic acid, 7-[(1R,2R,3R,5S)-3,5-dihydroxy-2-[(3R)-3-hydroxy-5-[3-(trifluoromethyl)phenyl]pentyl]cyclopentyl]-, (5Z)- | [Molecular Formula]
C24H33F3O5 | [MDL Number]
MFCD05863955 | [MOL File]
294856-01-2.mol | [Molecular Weight]
458.51 |
| Hazard Information | Back Directory | [Description]
A number of 17-phenyl trinor prostaglandin F2α (17-phenyl trinor PGF2α) derivatives have been approved for the treatment of glaucoma. Of these, the ones wherein the 13,14-double bond has been hydrogenated retain relatively good potency, but show a significantly reduced incidence of local irritant side effects. 17-trifluoromethylphenyl-13,14-dihydro trinor PGF2α bears an aromatic ring which is reminiscent of the trifluoromethyl-phenoxy ring of travoprost ((+)-fluprostenol isopropyl ester). As an ocular hypotensive agent, it would be expected that 17-trifluoromethylphenyl-13,14-dihydro trinor PGF2α would act very much like the free acid of latanoprost. | [Uses]
17-Trifluoromethylphenyl-13,14-dihydro trinor Prostaglandin F2α is a derivative of Bimatoprost acid (HY-125774)[1]. | [References]
[1] De Souza, F.I., Zumiotti, A.V., and Da Silva, C.F. Neuregulins 1-α and 1-β on the regeneration the peripheral nerves[J]. Acta Ortop Bras.
[2] Travoprost[J]. Reactions Weekly, 2009, 22 1: 40-41. DOI: 10.2165/00128415-200912530-00134
[3] BAHRAM RESUL. Phenyl-substituted prostaglandins: potent and selective antiglaucoma agents[J]. Journal of Medicinal Chemistry, 1993, 36 2: 243-248. DOI: 10.1021/jm00054a008 |
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