| Identification | Back Directory | [Name]
BENZYLTRIPHENYLPHOSPHONIUM BROMIDE POL& | [CAS]
29518-68-1 | [Synonyms]
1H-Benzimidazole-ethanamine
2-(2-Aminoethyl)benzimidazole
2-(Aminoethyl)-1H-benzimidazole
1H-Benzimidazole-ethanamine diHCl
1H-BENZIMIDAZOLE-ETHANAMINE . 2HCL
1H-Benzimidazole-2-ethanamine(9CI)
2-(1H-2-Benzoimidazolyl)-ethylamine
2-(1H-Benzo[d]iMidazol-2-yl)ethanaMine
BENZYLTRIPHENYLPHOSPHONIUM BROMIDE POL&
2-(1H-BENZO[D]IMIDAZOLE-2-YL)ETHAN-1-AMINE
1H-BENZIMIDAZOLE-ETHANAMINE DIHYDROCHLORIDE
2-(1H-benzimidazol-2-yl)ethanamine dihydrochloride
2-(1H-benzimidazol-2-yl)ethanamine(SALTDATA: 2HCl) | [Molecular Formula]
C9H11N3 | [MDL Number]
MFCD03702611 | [MOL File]
29518-68-1.mol | [Molecular Weight]
161.2 |
| Chemical Properties | Back Directory | [Melting point ]
160℃ | [Boiling point ]
400.0±25.0 °C(Predicted) | [density ]
1.225 | [storage temp. ]
Keep in dark place,Sealed in dry,Room Temperature | [pka]
11.82±0.10(Predicted) | [Appearance]
Off-white to light brown Solid | [InChIKey]
GJEPMYMUORZPMP-UHFFFAOYSA-N |
| Hazard Information | Back Directory | [Uses]
Polymer-supported Wittig reagent for clean olefinations of carbonyl compounds. | [reaction suitability]
reaction type: C-C Bond Formation
reaction type: solution phase peptide synthesis | [Synthesis]
GENERAL PROCEDURE: The general procedure for the synthesis of 2-(1H-benzo[d]imidazol-2-yl)ethylamine from o-phenylenediamine and β-alanine was modified with reference to the method of Phillips. L-amino acids were added to a stirring mixture of 4-nitrophthalimide and aqueous hydrochloric acid (5.5 M). The reaction mixture was heated under reflux conditions for 5 hours. Upon completion of the reaction, the blue reaction mixture was cooled to room temperature and allowed to stand overnight to allow the target product, 2-(1H-benzo[d]imidazol-2-yl)ethylamine, to crystallize and precipitate as hydrochloride. Subsequently, the reaction mixture was neutralized with 1 M K2CO3 solution to release the free base and extracted with ethyl acetate. The organic phase was evaporated to dryness and finally the product was purified by recrystallization from ethanol. | [References]
[1] Bioorganic and Medicinal Chemistry, 2014, vol. 22, # 1, p. 550 - 558
[2] Bulletin de la Societe Chimique de France, 1991, p. 255 - 259
[3] Collection of Czechoslovak Chemical Communications, 1950, vol. 15, p. 196,200 |
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