| Hazard Information | Back Directory | [Uses]
AChE-IN-59 (compounds 3b) is an AChE inhibitor, with an IC50 value of 0.05 μM. AChE-IN-59 can inhibit the aggregation of Aβ1-42, protect nerve cells and penetrate the blood-brain barrier well. AChE-IN-59 can be used for the research of Alzheimer's disease (AD)[1]. | [in vivo]
AChE-IN-59 (compounds 3b) (25 μM, 3 days) can alleviate the behavioral effects of AlCl3-induced zebrafish larval movement retardation[1]. | Animal Model: | zebrafish juveniles with 5 mg/L AlCl3 model[1] | | Dosage: | 5/10/25/50/100 μg/mL, | | Administration: | Soak drug administration | | Result: | Had certain therapeutic effect on AlCl3-induced zebrafish behavior inhibition, which was concentration-dependent. With the increase of compound concentration, the total distance of zebrafish larvae increased gradually. |
| [IC 50]
AChE: 0.05 μM (IC50); BChE: 4.68 μM (IC50); Aβ 1-42 | [References]
[1] Zhai J, et al. Design, synthesis, and evaluation of dual-target inhibitors for the treatment of Alzheimer's disease. Arch Pharm (Weinheim). 2024 Feb 8:e2300693. |
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