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2958668-54-5

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2958668-54-5 Structure

2958668-54-5 Structure

Identification	Back Directory
[Name] 2H-Indazole, 2-cyclopropyl-7-(difluoromethoxy)-4-(3,4,5-trimethoxyphenyl)-
[CAS] 2958668-54-5
[Synonyms] 2H-Indazole, 2-cyclopropyl-7-(difluoromethoxy)-4-(3,4,5-trimethoxyphenyl)-
[Molecular Formula] C20H20F2N2O4
[MOL File] 2958668-54-5.mol
[Molecular Weight] 390.38

Chemical Properties	Back Directory
[Boiling point ] 520.8±50.0 °C(predicted)
[density ] 1.36±0.1 g/cm3(Temp: 20 °C; Press: 760 Torr)(predicted)
[pka] -0.08±0.30(predicted)

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[Uses] Z21115 is an orally active inhibitor for phosphodiesterase 4 (PDE4), that inhibits PDE4D7 with IC50 of 10.5 nM. Z21115 inhibits Lipopolysaccharide (HY-D1056)-induced expression of IL-6, TNF-α and iNOS. Z21115 exhibits anti-inflammatory activity in DSS (HY-116282)-induced mouse colitis models without significant toxicity (1 g/kg)[1].
[IC 50] PDE4D7: 10.5 nM (IC₅₀); PDE4D: 65.7 nM (IC₅₀); PDE4B: 64.4 nM (IC₅₀)
[References] [1] Zheng L, et al., Discovery of novel N2-indazole derivatives as phosphodiesterase 4 inhibitors for the treatment of inflammatory bowel disease. Eur J Med Chem. 2024 Jul 31;277:116710. DOI:10.1016/j.ejmech.2024.116710

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Company Name:	TargetMol Chemicals Inc.
Tel:	15002134094
Website:	https://www.targetmol.cn/

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