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RET-IN-25 (compound 6b) is a RET kinase inhibitor with anticancer activity. RET-IN-25 inhibits medullary thyroid carcinoma (MTC) with IC50s of 3.6 μM (3 days) and 3.0 μM (6 days) against TT(C634R) MTC[1]. | [References]
[1] La Monica G, et al. Design and Synthesis of Novel Thieno [3, 2-c] quinoline Compounds with Antiproliferative Activity on RET-Dependent Medullary Thyroid Cancer Cells[J]. ACS Omega, 2023.. . . |
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