| Chemical Properties | Back Directory | [Boiling point ]
586.6±50.0 °C(predicted) | [density ]
1.352±0.06 g/cm3(Temp: 20 °C; Press: 760 Torr)(predicted) | [pka]
7.96±0.10(predicted) |
| Hazard Information | Back Directory | [Uses]
Tyrosinase-IN-27 (compound 6f) is a tyrosinase (TYR) inhibitor (IC50: 0.88 μM) that statically quenches TYR. Tyrosinase-IN-27 increases the hydrophobicity of the enzyme microenvironment by binding to TYR, reducing the content of α-helices in the enzyme and changing its secondary structure. Tyrosinase-IN-27 can be used in the food industry to effectively inhibit the browning of lotus root slices.[18][1]. | [References]
[1] He M, et al. Synthesis, anti-browning effect and mechanism research of kojic acid-coumarin derivatives as anti-tyrosinase inhibitors. Food Chem X. 2024 Jan 10;21:101128. DOI:10.1016/j.fochx.2024.101128 |
|
|