| Identification | Back Directory | [Name]
1H-Benzimidazole-2-acetamide, 6-[(4-fluorophenyl)methoxy]- | [CAS]
2969160-15-2 | [Synonyms]
1H-Benzimidazole-2-acetamide, 6-[(4-fluorophenyl)methoxy]- | [Molecular Formula]
C16H14FN3O2 | [MOL File]
2969160-15-2.mol | [Molecular Weight]
299.3 |
| Chemical Properties | Back Directory | [Boiling point ]
612.7±45.0 °C(predicted) | [density ]
1.375±0.06 g/cm3(Temp: 20 °C; Press: 760 Torr)(predicted) | [pka]
10.82±0.10(predicted) |
| Hazard Information | Back Directory | [Uses]
Monoamine Oxidase B inhibitor 5 (Compound 16d) is a selective and reversible inhibitor for monoamine oxidase B (hMAO-B) with an IC50 of 67.3 nM and a Ki of 82.5 nM. Monoamine Oxidase B inhibitor 5 exhibits good pharmacokinetic characters and weak toxicity in rats model. Monoamine Oxidase B inhibitor 5 alleviates MPTP-induced (HY-15608) motor impairment in Parkinson’s mouse model. Monoamine Oxidase B inhibitor 5 is blood-brain barrier (BBB) penetrate[1]. | [IC 50]
hMAO-B: 67.3 nM (IC50); hMAO-A: 26014 nM (IC50) | [References]
[1] Lv Y, et al., Discovery of novel benzimidazole derivatives as selective and reversible monoamine oxidase B inhibitors for Parkinson's disease treatment. Eur J Med Chem. 2024 Aug 5;274:116566. DOI:10.1016/j.ejmech.2024.116566 |
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