| Identification | Back Directory | [Name]
Azido-PEG6-CH2CO2t-butyl ester | [CAS]
297162-49-3 | [Synonyms]
N3-PEG6-CH2COOtBu
Azido-PEG6-C1-Boc
Azido-PEG6-CH2COOtBu
AZIDO-PEG6-CH2CO2TBU
Azido-PEG6-CH2COOH t-Bu Ester
Azido-PEG6-CH2CO2t-butyl ester | [Molecular Formula]
C18H35N3O8 | [MDL Number]
MFCD27977491 | [MOL File]
297162-49-3.mol | [Molecular Weight]
421.49 |
| Hazard Information | Back Directory | [Description]
Azido-PEG6-CH2CO2-t-Bu contain an azide group and a t-butyl ester. PEG spacer increases reagent's solubility in aqueous media. The azide (N3) group can react with alkyne, BCN, DBCO via Click Chemistry. The t-butyl protected carboxyl group can be deprotected under acidic condition. | [Uses]
Azido-PEG6-C1-Boc is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1]. Azido-PEG6-C1-Boc is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups. | [IC 50]
PEGs | [References]
[1] An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562 DOI:10.1016/j.ebiom.2018.09.005 |
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