| Chemical Properties | Back Directory | [Boiling point ]
675.6±65.0 °C(predicted) | [density ]
1.19±0.1 g/cm3(Temp: 20 °C; Press: 760 Torr)(predicted) | [form ]
Solid | [pka]
4.12±0.50(predicted) | [color ]
Off-white to light yellow |
| Hazard Information | Back Directory | [Uses]
STAT3-IN-12 is a potent STAT3 signal inhibitor that can inhibit IL-6 induced JAK/STAT3 signalling pathway activation. STAT3-IN-12 inhibits cancer cell growth, migration, and induce cell apoptosis as well as cycle arrest. STAT3-IN-12 can be used in cancer-related research, such as hepatocellular carcinoma (HCC) and oesophageal carcinoma[1]. | [in vivo]
STAT3-IN-12 (compound 24, intraperitoneal injection, 20, 40 mg/kg, daily for 24 days) displays obvious antitumor activity in a mouse HepG2 cell xenograft tumor model without no obvious toxicity[1].
| Animal Model: | HepG2 cell xenograft tumor model[1] | | Dosage: | 20, 40 mg/kg, daily for 24 days | | Administration: | Intraperitoneal injection | | Result: | Inhibited tumor growth without affecting the body weight. |
| [IC 50]
STAT3 | [References]
[1] Yi-Chen Liu, et al. Benzobis(imidazole) derivatives as STAT3 signal inhibitors with antitumor activity. DOI:10.1016/j.bmc.2022.116757 |
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