| Identification | Back Directory | [Name]
Fatostatin A | [CAS]
298197-04-3 | [Synonyms]
CS-2596
Fatostatin
Fatostatin A
Fatostatin HBr
Fatostatin A HBr
25B11 hydrobromide
Fatostatin hydrobromide
Fatostatin A HydrobroMide
Fatostatin - CAS 298197-04-3 - Calbiochem
2-(2-propylpyridin-4-yl)-4-p-tolylthiazole hydrobromide
4-[4-(4-methylphenyl)-2-thiazolyl]-2-propylpyridine hydrobromide
4-[4-(4-Methylphenyl)-2-thiazolyl]-2-propylpyridine MonohydrobroMide
Fatostatin hydrobromide - Fatostatin A hydrobromide | 125B11 hydrobromide | [Molecular Formula]
C18H19BrN2S | [MDL Number]
MFCD00760867 | [MOL File]
298197-04-3.mol | [Molecular Weight]
375.33 |
| Hazard Information | Back Directory | [Uses]
Fatostatin A is an inhibitor of sterol regulatory element binding protein (SREBP). Fatostatin A reverses hyperglycemia in diabetic mice. Cell permeable. Fatostatin A is used for the treatment and/or prevention of one or more metabolic disorders. | [General Description]
Fatostatin is a non-sterol diarylthiazole derivative. It prevents insulin-induced adipogenesis and lowers the amounts of fatty acid, triglyceride and low-density lipoprotein. Fatostatin has anti tumor and antimitotic properties. | [Biological Activity]
fatostatin a is an inhibitor of sterol regulatory element binding protein (srebp), which can inhibit the activation of srebp-1 and srebp-2[1].fatostatin a (0.1-1 μm; 3 days) inhibits the androgen-independent proliferation of prostate cancer cell in a manner independent of the known igf1 signaling pathway. fatostatin a inhibits insulin-induced fat formation in 3t3-l1 cells[2].fatostatin a (30 mg/kg; 150 ml; i.p.; daily for 28 days) prevents obese ob/ob mice from increasing their weight, blood sugar, and liver fat accumulation, even if they do not control the food intake of mice[1].[1]. kamisuki s, et al. a small molecule that blocks fat synthesis by inhibiting the activation of srebp. chem biol. 2009, 16(8): 882-92.[2]. choi y, et al. identification of bioactive molecules by adipogenesis profiling of organic compounds. j biol chem. 2003, 278(9): 7320-4. | [Biochem/physiol Actions]
Fatostatin hydrobromide is an SREBP inhibitor. Fatostatin hydrobromide inhibits fat production and lowers glucose levels in mice by inhibiting SREBP (Sterol Regulatory Element Binding Proteins). | [storage]
Store at +4°C |
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J & K SCIENTIFIC LTD.
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https://www.jkchemical.com |
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Sigma-Aldrich
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https://www.sigmaaldrich.cn |
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