| Identification | Back Directory | [Name]
3'-[(5,6,7,8-Tetrahydro[1]benzothieno[2,3-d]pyrimidine-4-yl)oxy]acetophenone | [CAS]
298207-77-9 | [Synonyms]
WAY-357919
VEGFR-2-IN-37
1-[3-(5,6,7,8-tetrahydrobenzothieno[2,3-d]pyrimidin-4-yloxy)phenyl]ethanone
3'-[(5,6,7,8-Tetrahydro[1]benzothieno[2,3-d]pyrimidine-4-yl)oxy]acetophenone
Ethanone, 1-[3-[(5,6,7,8-tetrahydro[1]benzothieno[2,3-d]pyrimidin-4-yl)oxy]phenyl]-
1-(3-((5,6,7,8-Tetrahydrobenzo[4,5]thieno[2,3-d]pyrimidin-4-yl)oxy)phenyl)ethan-1-one | [Molecular Formula]
C18H16N2O2S | [MOL File]
298207-77-9.mol | [Molecular Weight]
324.4 |
| Chemical Properties | Back Directory | [Melting point ]
148-149 °C | [Boiling point ]
519.4±50.0 °C(Predicted) | [density ]
1.305±0.06 g/cm3(Predicted) | [form ]
Solid | [pka]
2.07±0.20(Predicted) | [color ]
Off-white to pink |
| Hazard Information | Back Directory | [Uses]
VEGFR-2-IN-37 (compound 12) is an inhibitor of VEGFR-2. The inhibition rate at 200 μM was approximately 56.9 μM. VEGFR-2-IN-37 is a potential inhibitor of human umbilical vein endothelial cell (HUVEC) proliferation[1]. | [References]
[1] Perspicace E, et al. Design, synthesis and biological evaluation of new classes of thieno[3,2-d]pyrimidinone and thieno[1,2,3]triazine as inhibitor of vascular endothelial growth factor receptor-2 (VEGFR-2). Eur J Med Chem. 2013 May;63:765-81. DOI:10.1016/j.ejmech.2013.03.022 |
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