2983118-29-0

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2983118-29-0 Structure

Chemical Properties	Back Directory
[density ] 1.43±0.1 g/cm3(Temp: 20 °C; Press: 760 Torr)(predicted)
[form ] Solid
[pka] 13.64±0.46(predicted)
[color ] White to off-white

Hazard Information	Back Directory
[Uses] GPR139 agonist-2 (compound 20a) is a potent GPR139 agonist with an EC50 of 24.7 nM. GPR139 agonist-2 rescues the social interaction deficits and alleviates cognitive deficits in murine schizophrenia models. GPR139 agonist-2 has the potential for antischizophrenia drug research[1].
[References] [1] Jianhang Mao, et al. Design and Synthesis of Novel GPR139 Agonists with Therapeutic Effects in Mouse Models of Social Interaction and Cognitive Impairment. J Med Chem. 2023 Oct 26;66(20):14011-14028. DOI:10.1021/acs.jmedchem.3c01034

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