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NH2-UAMC1110 TFA is a UAMC1110 derivative that can be used in the synthesis of FAPI-QS. UAMC1110 is a fibroblast activation protein (FAP) inhibitor. FAPI-QS is a chelating agent that can be used to synthesize high tumor selectivity and high dose radiotracers for the diagnosis and treatment of tumors[1][2]. | [References]
[1] Euy Sung Moon, et al. Targeting fibroblast activation protein (FAP): next generation PET radiotracers using squaramide coupled bifunctional DOTA and DATA5m chelators. EJNMMI Radiopharm Chem. 2020 Jul 29;5(1):19. DOI:10.1186/s41181-020-00102-z
[2] Kristina Hoot Young, et al. Preclinical combination of radiation and fibroblast activation protein inhibition in pancreatic cancer. Journal of Clinical Oncology. 2016, 34 (15). |
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