| Identification | Back Directory | [Name]
GDCNF-11 | [CAS]
2991588-80-6 | [Synonyms]
GDCNF-11
2-Thiopheneacetamide, α-[[4-[[1-[2-[4-[2-[[2-amino-9-[(4-methoxy-3,5-dimethyl-2-pyridinyl)methyl]-9H-purin-6-yl]amino]ethyl]-1-piperidinyl]-2-oxoethyl]-1H-1,2,3-triazol-4-yl]methoxy]-3-chlorophenyl](2-chloroacetyl)amino]-N-(2-phenylethyl)- | [Molecular Formula]
C48H53Cl2N13O5S | [MOL File]
2991588-80-6.mol | [Molecular Weight]
994.99 |
| Hazard Information | Back Directory | [Uses]
GDCNF-11 is a HIM-PROTAC GPX4 degrader based on the chaperone protein HSP90. GDCNF-11 promotes the ubiquitination and degradation of GPX4 through the HSP 90 chaperone complex, reduces endogenous GPX4 expression to induce ferroptosis in HT-1080 cells, and the DC50 value is 0.08 μM (Pink: Target protein ligand (HY-153748); Blue: HSP90 ligand (HY-10212); Black: Linker (HY-W169526))[1]. | [References]
[1] Dong J, et al. Heat Shock Protein 90 Interactome-Mediated Proteolysis Targeting Chimera (HIM-PROTAC) Degrading Glutathione Peroxidase 4 to Trigger Ferroptosis[J]. Journal of Medicinal Chemistry, 2024. DOI:10.1021/acs.jmedchem.4c01518 |
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