| Identification | Back Directory | [Name]
LSD1-IN-35 | [CAS]
2992690-04-5 | [Synonyms]
LSD1-IN-35
1,4-Benzenediamine, N1,N1-diethyl-N4-[2-[4-(methylsulfonyl)phenyl]-4-quinazolinyl]- | [Molecular Formula]
C25H26N4O2S | [MOL File]
2992690-04-5.mol | [Molecular Weight]
446.57 |
| Chemical Properties | Back Directory | [Boiling point ]
586.6±50.0 °C(predicted) | [density ]
1.261±0.06 g/cm3(Temp: 20 °C; Press: 760 Torr)(predicted) | [pka]
7.01±0.44(predicted) |
| Hazard Information | Back Directory | [Uses]
LSD1-IN-35 (Compound Z-1) is a selective LSD1 Inhibitor (IC50: 108 nM). LSD1-IN-35 inhibits the demethylation on H3K4me1/2. LSD1-IN-35 is an immunomodulator. LSD1-IN-35 promotes response of gastric cancer cells to T-cell killing effect by decreasing PD-L1 expression and further attenuates the PD-1/PD-L1 interaction[1]. | [IC 50]
LSD1 | [References]
[1] Bo Wang, et al. Discovery of 2-Aryl-4-aminoquinazolin-Based LSD1 Inhibitors to Activate Immune Response in Gastric Cancer. Med. Chem. 2024, 67, 18, 16165-16184. |
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