| Identification | Back Directory | [Name]
Benzamide, 5-[4-[(aminocarbonyl)hydroxyamino]-1-butyn-1-yl]-2-[2-[4-[(R)-(4-chlorophenyl)phenylmethyl]-1-piperazinyl]ethoxy]- | [CAS]
299460-62-1 | [Synonyms]
UCB35440
UCB-35440
UCB 35440
Benzamide, 5-[4-[(aminocarbonyl)hydroxyamino]-1-butyn-1-yl]-2-[2-[4-[(R)-(4-chlorophenyl)phenylmethyl]-1-piperazinyl]ethoxy]- | [Molecular Formula]
C31H34ClN5O4 | [MDL Number]
MFCD09475570 | [MOL File]
299460-62-1.mol | [Molecular Weight]
576.09 |
| Hazard Information | Back Directory | [Uses]
UCB-35440 is an orally active histamine H1 receptor antagonist and 5-lipoxygenase inhibitor. UCB-35440 inhibits LTB4 formation in human whole blood and reduces polymorphonuclear cell infiltration in mouse models. UCB-35440 inhibits histamine-stimulated bronchoconstriction and reduces skin inflammation in guinea pigs. UCB-35440 can be used for research on asthma and skin inflammation[1][2]. | [References]
[1] Giannaras A, et al. The effect of a novel, dual function histamine H1 receptor antagonist/5-lipoxygenase enzyme inhibitor on in vivo dermal inflammation and extravasation. Eur J Pharmacol. 2005 Jan 4;506(3):265-71. DOI:10.1016/j.ejphar.2004.11.003
[2] Oliver Werz, et al. Pharmacological intervention with 5-lipoxygenase: new insights and novel compounds. Expert Opin Ther Patents. 2005 May 10; 15(5):505-519. |
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