| Identification | Back Directory | [Name]
(Pro3)-Gastric Inhibitory Polypeptide (human) | [CAS]
299898-52-5 | [Synonyms]
(Pro3)-Gastric Inhibitory Polypeptide (human)
(Pro?)-Gastric Inhibitory Polypeptide (human) trifluoroacetate salt |
| Hazard Information | Back Directory | [Uses]
(Pro3) GIP, human ((Pro3) Gastric Inhibitory Peptide, human) is an efficacious, stable and specific human GIP receptor (hGIPR) full agonist. (Pro3) GIP, human has high binding affinity for human GIPR with Ki/ Kd values of 0.90 nM. (Pro3) GIP, human can be used for the research of obesity-related diabetes[1][2]. | [in vivo]
(Pro3) GIP, human has comparatively weak partial agonist effect in rodent models[2]. | [References]
[1] Victor A Gault, et al. Chemical ablation of gastric inhibitory polypeptide receptor action by daily (Pro3)GIP administration improves glucose tolerance and ameliorates insulin resistance and abnormalities of islet structure in obesity-related diabetes. Diabetes. 2005 Aug;54(8):2436-46. DOI:10.2337/diabetes.54.8.2436
[2] A H Sparre-Ulrich, et al. Species-specific action of (Pro3)GIP - a full agonist at human GIP receptors, but a partial agonist and competitive antagonist at rat and mouse GIP receptors. Br J Pharmacol. 2016 Jan;173(1):27-38. DOI:10.1111/bph.13323 |
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