| Chemical Properties | Back Directory | [storage temp. ]
2-8°C | [solubility ]
DMSO: 2mg/mL, clear | [form ]
powder | [color ]
white to beige | [InChI]
1S/C21H33N3O.ClH/c1-2-3-4-5-6-7-8-9-11-18-13-15-19(16-14-18)21-23-20(25-24-21)12-10-17-22;/h13-16H,2-12,17,22H2,1H3;1H | [InChIKey]
ZJJXKBLUUGLWDW-UHFFFAOYSA-N | [SMILES]
CCCCCCCCCCC1=CC=C(C=C1)C2=NOC(CCCN)=N2.Cl |
| Hazard Information | Back Directory | [Uses]
SLF1081851 (hydrochloride) is a Spns2 inhibitor, inhibits S1P release (IC50=1.93 μM). SLF1081851 (hydrochloride) plays a key role in the development and immune system[1]. | [Biological Activity]
Potent and selective inhibitor of Spns2 (spinster homolog 2) sphingosine-1-phosphate (SP1) transporter.
Spns2 inhibitor 16d (SLF1081851) is a potent and selective inhibitor of Spns2 (spinster homolog 2) sphingosine-1-phosphate (SP1) transporter. Spns2 inhibitor 16d (SLF1081851) decreases circulating plasma S1P and lymphocytes in mice and rats. Apparentlyit locks Spns2 in the inward-facing state. | [References]
[1] Russell Fritzemeier, et al. Discovery of In Vivo Active Sphingosine-1-phosphate Transporter (Spns2) Inhibitors. J Med Chem. 2022, 65, 11. DOI:10.1021/acs.jmedchem.1c02171 |
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| Company Name: |
Enzo Biochem Inc
|
| Tel: |
Enzo Biochem Inc. 13797054060 |
| Website: |
www.enzo.com |
| Company Name: |
Merck KGaA
|
| Tel: |
21-20338288 |
| Website: |
www.sigmaaldrich.cn |
|