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2999794-78-2

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2999794-78-2 Structure

2999794-78-2 Structure

Identification	Back Directory
[Name] NNRT-IN-2
[CAS] 2999794-78-2
[Synonyms] NNRT-IN-2
[Molecular Formula] C19H14F3N5O3
[MOL File] 2999794-78-2.mol
[Molecular Weight] 417.34

Chemical Properties	Back Directory
[density ] 1.522±0.14 g/cm3(Temp: 25 °C; Press: 760 Torr)(predicted)
[pka] 8.332±0.20(predicted)

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[Uses] NNRT-IN-2 (compound 7w) is an orally available non-nucleoside reverse transcriptase inhibitor (NNRTI) with broad inhibitory effects on wild-type HIV-1 and mutant strains. NNRT-IN-2 inhibits HIV-1 reverse transcriptase with an EC50 of 22 nM. NNRT-IN-2 is insensitive to CYP and hERG and has good safety and pharmacokinetic characteristics[1].
[References] [1] Zhao LM, et al. Structure-based design of novel heterocycle-substituted ATDP analogs as non-nucleoside reverse transcriptase inhibitors with improved selectivity and solubility. Acta Pharm Sin B. 2023 Dec;13(12):4906-4917. DOI:10.1016/j.apsb.2023.07.008

2999794-78-2 suppliers list

Company Name:	TargetMol Chemicals Inc.
Tel:	15002134094
Website:	https://www.targetmol.cn/

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