| Identification | Back Directory | [Name]
Ribitol,2,5-anhydro-1-deoxy-3,4-O-isopropylidene-1-(1-nitrosoureido)-, DL- (8CI) | [CAS]
30002-86-9 | [Synonyms]
Ribitol,2,5-anhydro-1-deoxy-3,4-O-isopropylidene-1-(1-nitrosoureido)-, DL- (8CI) | [Molecular Formula]
C9H15N3O5 | [MOL File]
30002-86-9.mol | [Molecular Weight]
245.24 |
| Hazard Information | Back Directory | [Description]
Azadirone, a limonoid tetranortriterpene, induces death receptors and sensitizes human cancer cells to tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) through a p53 protein-independent mechanism. Azadirone can sensitize cancer cells to tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) through ROS-ERK-CHOP-mediated up-regulation of DR5 and DR4 signaling, down-regulation of cell survival proteins, and up-regulation of proapoptotic proteins. | [Uses]
Azadirone sensitized cancer cells to TNF-related apoptosis-inducing ligand (TRAIL) through ROS-ERK-CHOP-mediated up-regulation of DR5 and DR4 expression, down-regulation of cell survival proteins, and up-regulation of proapoptotic proteins (Bid). Azadirone has antiplasmodial activity[1][2]. | [References]
[1] Gupta SC, et al. Azadirone, a limonoid tetranortriterpene, induces death receptors and sensitizes human cancer cells to tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) through a p53 protein-independent mechanism: evidence for the role of the ROS-ERK-CHOP-death receptor pathway. J Biol Chem. 2013 Nov 8;288(45):32343-32356. DOI:10.1074/jbc.M113.455188
[2] Chianese G, et al. Antiplasmodial triterpenoids from the fruits of neem, Azadirachta indica. J Nat Prod. 2010 Aug 27;73(8):1448-52. DOI:10.1021/np100325q |
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