| Identification | Back Directory | [Name]
kujimycin B | [CAS]
30042-37-6 | [Synonyms]
A-20338-N2
Lankamycin
kujimycin B
Antibiotic A-20338-N2
Oxacyclotetradecane-2,10-dione, 4-[(4-O-acetyl-2,6-dideoxy-3-C-methyl-3-O-methyl-α-L-xylo-hexopyranosyl)oxy]-12-(acetyloxy)-6-[(4,6-dideoxy-3-O-methyl-β-D-xylo-hexopyranosyl)oxy]-9-hydroxy-14-[(1S,2S)-2-hydroxy-1-methylpropyl]-3,5,7,9,11,13-hexamethyl-, (3R,4S,5R,6S,7S,9S,11R,12S,13S,14R)- | [Molecular Formula]
C42H72O16 | [MDL Number]
MFCD01939678 | [MOL File]
30042-37-6.mol | [Molecular Weight]
833.01 |
| Chemical Properties | Back Directory | [Melting point ]
Double mp, 147-150° and 181-182° | [alpha ]
D20 -94° (c = 1.23 in alc.) | [Boiling point ]
846.0±65.0 °C(Predicted) | [density ]
1.19±0.1 g/cm3(Predicted) | [pka]
12.75±0.70(Predicted) |
| Hazard Information | Back Directory | [Uses]
Lankamycin, a macrolide antibiotic, shows moderate antimicrobial activity against several gram-positive bacteria, acting as a synergistic pair with carbocyclic antibiotic Lankacidin C (HY-121412) by binding to the ribosome exit tunnel[1]. | [Definition]
ChEBI: Lankamycin is a macrolide. | [References]
[1] Mingge Zhang, et al. Accumulation of lankamycin derivative with a branched-chain sugar from a blocked mutant of chalcose biosynthesis in Streptomyces rochei 7434AN4. Bioorg Med Chem Lett. 2023 Jan 15:80:129125. DOI:10.1016/j.bmcl.2023.129125 |
|
|