| Identification | Back Directory | [Name]
8-Nonenoic acid, 2-[[(1,1-dimethylethoxy)carbonyl]amino]-, (2S)- | [CAS]
300831-21-4 | [Synonyms]
non-8-enoic acid
Boc-(S)-2-aminonon-8-enoicacid
(S)-N-Boc-2-(6'-heptenyl)glycine
Boc- (2S)-2-Amino-8-nonenoic acid
(S)-2-(Boc-amino)-8-nonenoic Acid
(S)-2-(Boc-amino)non-8-enoic acid
2-[(TERT-BUTOXYCARBONYL)AMINO]NON-8-ENOIC ACID
(2S)-2-{[(tert-butoxy)carbonyl]amino}non-8-enoic acid
(2S)-2-[[(1,1-Dimethylethoxy)carbonyl]amino]-8-nonenoic acid
(2S)-2-[(2-methylpropan-2-yl)oxycarbonylamino]non-8-enoic acid
8-Nonenoic acid, 2-[[(1,1-dimethylethoxy)carbonyl]amino]-, (2S)- | [Molecular Formula]
C14H25NO4 | [MDL Number]
MFCD03094930 | [MOL File]
300831-21-4.mol | [Molecular Weight]
271.35 |
| Chemical Properties | Back Directory | [Boiling point ]
422.7±45.0 °C(Predicted) | [density ]
1.035±0.06 g/cm3(Predicted) | [storage temp. ]
Sealed in dry,2-8°C | [pka]
4.01±0.21(Predicted) | [Appearance]
Colorless to light yellow Liquid |
| Hazard Information | Back Directory | [Synthesis]
(S)-2-Aminonon-8-enoic acid (1.5 g, 1.0 eq.) and di-tert-butyl dicarbonate (2.01 g, 1.05 eq.) were reacted in a solvent mixture of THF/H2O (7.5 mL/2.5 mL) in the presence of triethylamine (TEA, 2.2 g, 2.5 eq.) for 5 h at 15-25°C. After completion of the reaction, ethyl acetate (EA, 5 mL) was added. After completion of the reaction, ethyl acetate (EA, 5 mL) was added and the pH was adjusted to 6.5 with 2N HCl. After phase separation, the aqueous phase was extracted with ethyl acetate (5 mL × 3). The organic phases were combined, dried over anhydrous sodium sulfate, filtered and the solvent was concentrated to give (S)-2-((tert-butoxycarbonyl)amino)nona-8-enoic acid as a white solid 2.02 g in 85% yield. | [References]
[1] Patent: CN108689909, 2018, A. Location in patent: Paragraph 0069; 0070
[2] Patent: WO2009/46098, 2009, A1. Location in patent: Page/Page column 77-79
[3] Patent: WO2011/63501, 2011, A1. Location in patent: Page/Page column 42
[4] Patent: WO2011/63502, 2011, A1. Location in patent: Page/Page column 64 |
|
|