| Identification | Back Directory | [Name]
GSA 10 | [CAS]
300833-95-8 | [Synonyms]
GSA 10
propyl 4-[(1-hexyl-4-hydroxy-2-oxo-quinoline-3-carbonyl)amino]benzoate
Propyl 4-(1-hexyl-4-hydroxy-2-oxo-1,2-dihydroquinoline-3-carboxamido)benzoate
4-[[(1-Hexyl-1,2-dihydro-2-oxo-3-quinolinyl)carbonyl]amino]benzoic acid propyl ester | [Molecular Formula]
C26H30N2O5 | [MDL Number]
MFCD01128015 | [MOL File]
300833-95-8.mol | [Molecular Weight]
450.53 |
| Chemical Properties | Back Directory | [Boiling point ]
620.2±55.0 °C(Predicted) | [density ]
1.240±0.06 g/cm3(Predicted) | [storage temp. ]
Store at -20°C | [solubility ]
Soluble to 5 mM in DMSO with gentle warming | [form ]
Powder | [pka]
4.50±1.00(Predicted) | [color ]
White to light yellow | [InChI]
1S/C26H30N2O5/c1-3-5-6-9-16-28-21-11-8-7-10-20(21)23(29)22(25(28)31)24(30)27-19-14-12-18(13-15-19)26(32)33-17-4-2/h7-8,10-15,29H,3-6,9,16-17H2,1-2H3,(H,27,30) | [InChIKey]
MDLUYYGRCGDKGL-UHFFFAOYSA-N | [SMILES]
OC(C1=CC=CC=C1N2CCCCCC)=C(C(NC3=CC=C(C(OCCC)=O)C=C3)=O)C2=O |
| Hazard Information | Back Directory | [Description]
Smoothened (SMO) is a cell surface receptor that, with Patched, mediates hedgehog signaling to regulate gene expression through the Gli transcription factors. GSA 10 is a quinolinecarboxamide derivative that acts as an agonist of SMO. By acting at SMO, GSA 10 has been shown to promote the differentiation of multipotent mesenchymal progenitor cells into osteoblasts (EC50 = 1.2 μM). Most notably, GSA 10 does not recognize the classic cyclopamine binding site as do other SMO agonists and as such has been used to characterize a novel SMO active site. | [Uses]
GSA 10 is a novel small-molecule positive modulator of smoothened. GSA 10 may have therapeutic interests in regenerative medicine. | [References]
[1] TATIANA GOROJANKINA. Discovery, molecular and pharmacological characterization of GSA-10, a novel small-molecule positive modulator of Smoothened.[J]. Molecular Pharmacology, 2013, 83 5: 1020-1029. DOI: 10.1124/mol.112.084590 |
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| Company Name: |
SPIRO PHARMA
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| Tel: |
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| Website: |
www.spiropharma.com.cn |
| Company Name: |
Lynnchem
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86-(0)29-85992781 17792393971 |
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http://www.lynnchem.com/ |
| Company Name: |
Novachemistry
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44-20819178-90 02081917890 |
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https://www.novachemistry.com/ |
| Company Name: |
Energy Chemical
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021-58432009 400-005-6266 |
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http://www.energy-chemical.com |
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NewCan Biotech Limited
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+86-0571-86912261 +86-15658003402 |
| Website: |
https://www.newcanbio.com/ |
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