300833-95-8

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300833-95-8 Structure

Identification	Back Directory
[Name] GSA 10
[CAS] 300833-95-8
[Synonyms] GSA 10 propyl 4-[(1-hexyl-4-hydroxy-2-oxo-quinoline-3-carbonyl)amino]benzoate Propyl 4-(1-hexyl-4-hydroxy-2-oxo-1,2-dihydroquinoline-3-carboxamido)benzoate 4-[[(1-Hexyl-1,2-dihydro-2-oxo-3-quinolinyl)carbonyl]amino]benzoic acid propyl ester
[Molecular Formula] C26H30N2O5
[MDL Number] MFCD01128015
[MOL File] 300833-95-8.mol
[Molecular Weight] 450.53

Chemical Properties	Back Directory
[Boiling point ] 620.2±55.0 °C(Predicted)
[density ] 1.240±0.06 g/cm3(Predicted)
[storage temp. ] Store at -20°C
[solubility ] Soluble to 5 mM in DMSO with gentle warming
[form ] Powder
[pka] 4.50±1.00(Predicted)
[color ] White to light yellow

Safety Data	Back Directory
[Symbol(GHS) ] GHS07
[Signal word ] Warning
[Hazard statements ] H302
[Precautionary statements ] P280-P305+P351+P338

Hazard Information	Back Directory
[Description] Smoothened (SMO) is a cell surface receptor that, with Patched, mediates hedgehog signaling to regulate gene expression through the Gli transcription factors. GSA 10 is a quinolinecarboxamide derivative that acts as an agonist of SMO. By acting at SMO, GSA 10 has been shown to promote the differentiation of multipotent mesenchymal progenitor cells into osteoblasts (EC₅₀ = 1.2 μM). Most notably, GSA 10 does not recognize the classic cyclopamine binding site as do other SMO agonists and as such has been used to characterize a novel SMO active site.
[Uses] GSA 10 is a novel small-molecule positive modulator of smoothened. GSA 10 may have therapeutic interests in regenerative medicine.
[References] [1] TATIANA GOROJANKINA. Discovery, molecular and pharmacological characterization of GSA-10, a novel small-molecule positive modulator of Smoothened.[J]. Molecular Pharmacology, 2013, 83 5: 1020-1029. DOI: 10.1124/mol.112.084590

Spectrum Detail	Back Directory
[Spectrum Detail] GSA 10(300833-95-8)¹HNMR

300833-95-8 suppliers list

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