| Identification | Back Directory | [Name]
1-Piperazineacetamide, N-[4-(aminosulfonyl)phenyl]-4-[2-[2-(diethylamino)ethyl]-2,3-dihydro-1,3-dioxo-1H-benz[de]isoquinolin-6-yl]- | [CAS]
3009842-92-3 | [Synonyms]
1-Piperazineacetamide, N-[4-(aminosulfonyl)phenyl]-4-[2-[2-(diethylamino)ethyl]-2,3-dihydro-1,3-dioxo-1H-benz[de]isoquinolin-6-yl]- | [Molecular Formula]
C30H36N6O5S | [MOL File]
3009842-92-3.mol | [Molecular Weight]
592.71 |
| Hazard Information | Back Directory | [Uses]
CA IX-IN-2 (Compound 9o) is an inhibitor for carbonic anhydrase (CA), that inhibits CA IX, CA XII and CA II with an IC50 of 5.6, 7.4 and 430 nM, respectively. CA IX-IN-2 inhibits the proliferation of cancer cell HCT-116, SW480, MDA-MB 231 and MCF-7, with IC50s of 14.63-29.33 μM. CA IX-IN-2 intercalates DNA, arrests cell cycle at G1/S phase, and induces apoptosis in MDA-MB-231. CA IX-IN-2 affects the mitochondrial membrane potential (MMP), increases the intracellular ROS levels, causes mitochondrial damage, and inhibits the cell migration of MDA-MB-231. CA IX-IN-2 exhibits antitumor efficacy in mouse models[1]. | [IC 50]
CA Ⅸ: 5.6 nM (IC50); CA XII: 7.4 nM (IC50); CA Ⅱ: 430 nM (IC50) | [References]
[1] Liang Q, et al., Discovery of novel 1,8-naphthalimide piperazinamide based benzenesulfonamides derivatives as potent carbonic anhydrase IX inhibitors and ferroptosis inducers for the treatment of triple-negative breast cancer. Bioorg Chem. 2024 Sep;150:107596. DOI:10.1016/j.bioorg.2024.107596 |
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