| Identification | Back Directory | [Name]
RH01386 | [CAS]
301177-36-6 | [Synonyms]
RH01386
RH 01386,βTC6 cells,RH01386,RH-01386,inhibit,Apoptosis,Inhibitor,type 2 diabetes,β cell
5-Pyrimidinecarbonitrile, 4-cyclohexyl-1,6-dihydro-2-[[2-nitro-4-(trifluoromethyl)phenyl]thio]-6-oxo- | [Molecular Formula]
C18H15F3N4O3S | [MDL Number]
MFCD01313040 | [MOL File]
301177-36-6.mol | [Molecular Weight]
424.4 |
| Chemical Properties | Back Directory | [Boiling point ]
514.8±60.0 °C(Predicted) | [density ]
1.54±0.1 g/cm3(Predicted) | [form ]
Solid | [pka]
4.63±0.50(Predicted) | [color ]
Off-white to light yellow |
| Hazard Information | Back Directory | [Uses]
RH01386 is a small molecule that can prevent endoplasmic reticulum stress (ERS)-induced β cell dysfunction and death, and inhibits proapoptotic gene expression. RH01386 restores ERS-impaired glucose-stimulated insulin secretion responses. RH01386 has the potential for type 2 diabetes treatment[1]. | [References]
[1] Tran K, et al. Identification of small molecules that protect pancreatic β cells against endoplasmic reticulum stress-induced cell death.ACS Chem Biol. 2014 Dec 19;9(12):2796-806. DOI:10.1021/cb500740d |
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