| Chemical Properties | Back Directory | [Boiling point ]
554.5±35.0 °C(predicted) | [density ]
1.052±0.06 g/cm3(Temp: 20 °C; Press: 760 Torr)(predicted) | [pka]
4.83±0.12(predicted) |
| Hazard Information | Back Directory | [Uses]
JGB-1-155 is a positive allosteric modulators (N-PAMs), which enhances the activity of nicotinamide phosphoribosyltransferase NAMPT with EC50 of 3.29 μM. JGB-1-155 counteracts the oxidative stress, through upregulating the NAD+ in THP-1 human monocytes. JGB-1-155 attenuates TNFα-induced ROS in HT-22 cells [1]. | [References]
[1] Gordon-Blake J, et al., Nicotinamide Phosphoribosyltransferase Positive Allosteric Modulators Attenuate Neuronal Oxidative Stress. ACS Med Chem Lett. 2024 Jan 24;15(2):205-214. DOI:10.1021/acsmedchemlett.3c00391 |
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