| Chemical Properties | Back Directory | [Boiling point ]
629.3±55.0 °C(predicted) | [density ]
1.147±0.06 g/cm3(Temp: 20 °C; Press: 760 Torr)(predicted) | [pka]
15.00±0.20(predicted) |
| Hazard Information | Back Directory | [Uses]
RyR2 stabilizer-1 (compound 12a) is a potent RyR2 stabilizer and SERCA2a activator with EC50s of 2.7 μM for RyR2 and 383 nM for SERCA2. RyR2 stabilizer-1 inhibits Ca2+ leakage from the SR RyR2 while promoting SERCA2 to pump Ca2+ back to SR, which make RyR2 stabilizer-1 possible to prevent cardiac arrhythmias[1]. | [References]
[1] Gyuzel Y. Mitronova, et al. 1,4-Benzothiazepines with Cyclopropanol Groups and Their Structural Analogues Exhibit Both RyR2-Stabilizing and SERCA2aStimulating Activities. Journal of Medicinal Chemistry. 2023， Article ASAP. DOI:10.1021/acs.jmedchem.3c01235 |
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| Company Name: |
TargetMol
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| Telephone: |
400-821-0310 15002144251 |
| Website: |
www.targetmol.cn/ |
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